Carbenoxolone sodium.

Plasma 11-hydroxycorticoid levels after carbenoxolone sodium.

A definite rise in plasma 11-hydroxycorticoid levels has been shown in eight patients with duodenal ulcer following the oral administration of carbenoxolone sodium. A similar rise was seen in one patient with sarcoidosis whose pituitary A.C.T.H. secretion had been acutely suppressed with dexamethasone. No such rise, however, was seen in three patients suffering from adrenal insufficiency. It is...

Morphological observations on gastric ulcers treated with carbenoxolone sodium.

Carbenoxolone, being a pentacyclic triterpene, is a drug which has a steroid-like structure, and despite anitiinflammatory and mineralocorticoid-like effects resembling those of steroid has shown considerable success in producing healing of gastric ulceration (Doll, Hill, Hutton, and Underwood, 1962; Horwich and Galloway, 1965). The mode of action of carbenoxolone is not yet understood. The dru...

Controlled comparison of cimetidine and carbenoxolone sodium in gastric ulcer.

Fifty-four outpatients with endoscopically diagnosed benign gastric ulcer were allocated at random to treatment with either cimetidine 800 mg daily for six weeks or carbenoxolone sodium 300 mg daily for one week then 150 mg daily for five weeks. Ulcers were reassessed by endoscopy at the end of the trial. The endoscopist was unaware of the treatment and did not take part in the clinical care of...

Hypokalaemic myopathy and myoglobinuria due to carbenoxolone sodium.

STAMEY, T.A. (1956) The pathogenesis and implications of the electrolyte imbalance in ureterosigmoidostomy. Surgery, Gynaecology and Obstetrics, 103, 736. STRONG, J.A. (1951) Serum potassium deficiency during treatment with sodium, PAS and liquorice extract. British Medical Journal, 2, 998. TANNEN, R.L. (1969) The relationship between urinary pH and acid excretion; the influence of urine flow r...

Treatment of Gastric Ulcer with Carbenoxolone Sodium and Oestrogens.